Periodontal diseases are often considered to be genetic, microbial, and influenced by individual risk factors. This article explores the scientific basis of these causes and the treatment strategies available for patients with periodontal diseases.

Genetic Origins of Periodontal Disease

Periodontal diseases are classically described as inflammatory diseases caused by bacterial infections that can lead to the destruction of tooth-supporting tissues. In some cases, patients may have a genetic predisposition to these diseases, which can affect the severity and distribution of periodontal diseases within the population. This genetic component is evident in:

  • Rare Diseases:
    Patients with certain systemic genetic syndromes may experience early and aggressive signs of periodontitis due to abnormalities in the genes responsible for the proper structuring of periodontal tissues or genes involved in immune-inflammatory responses (e.g., Marfan syndrome, Hellers-Danlos syndrome, hypophosphatasia, leukocyte adhesion deficiency, Papillon-Lefevre syndrome, Chediak-Higiashi syndrome, Down syndrome).
  • Family History:
     A family history of periodontal diseases should be explored during the initial consultation. Studies have shown that family components are frequently established, particularly in aggressive periodontal diseases. However, it remains unclear whether this is due to genetic factors, environmental factors, or both.
  • Ethnic Influences:
     Studies based on national health surveys have shown that certain ethnic groups are more severely affected by periodontal diseases. However, it is difficult to determine if these disparities are due to innate characteristics or socio-economic factors that influence access to balanced nutrition, prevention, and medical care.


In response to the question, "Are periodontal diseases genetic?" the answer seems to be both no and yes:

  • No, because the strict definition of a genetic disease in medicine does not (yet?) apply to periodontal diseases.
  • Yes, because the composition and cellular behavior of periodontal tissues are dependent on an individual's genetic code, making periodontal diseases polygenic.

The development of genome sequencing techniques and artificial intelligence may help further define the genetic component of these diseases and lead to the development of susceptibility tests and early screening methods.


What are the main causes of periodontal diseases?

Periodontal diseases are caused by a combination of genetic factors, bacterial infections, and individual risk factors.

Can periodontal diseases be prevented?

While genetic predispositions cannot be changed, maintaining good oral hygiene and a healthy lifestyle can help prevent periodontal diseases or reduce their severity.

How are periodontal diseases treated?

Treatment strategies for periodontal diseases depend on the individual case and may include improved oral hygiene, lifestyle changes, and therapeutic interventions.